06 - Artigos Originais: Atrofia Cortical Durante Tratamento com Lítio em Níveis Terapêuticos, Perfenazina e Paroxetina: Relato de Caso e Revisão da Literatura

Cortical Atrophy During Treatment with Lithium in Therapeutic Levels, Perphenazine and Paroxetine: Case Report and Literature Review. Atrofia Cortical Durante Tratamento com Lítio em Níveis Terapêuticos, Perfenazina e Paroxetina: Relato de Caso e Revisão da Literatura. . Luiz Renato Gazzola. . Summary. . We present, in clinical case conference format, a case in which delirium developed and rapidly progressed to mild dementia in a previously healthy (from the neurological standpoint) 40 years old woman being treated with lithium, paroxetine, and perphenazine for bipolar disorder I with psychotic features. The unusual aspect of the case is the fact that it was associated with de novo cortical and cerebellar atrophy, as evidenced by two MRIs performed six months apart. We present our possible explanation for the findings as medication-induced toxic dementia, as well as the differential diagnosis (including a detailed discussion of the possible causes of dementia in this age group). We discuss some unusual drug interactions, and offer a review of the pertinent literature.. . Key-words: Cortex, Cerebral; Cerebellar Cortex; Atrophy; Dementia; Delirium; Drug Interactions, Drug Toxicity; Lithium; Perphenazine; Paroxetine. . We will present a clinical case and its differential diagnosis, followed by discussion and literature review. The format adopted for ...

Palavras chave: case, years, during, years old, cortical, old, through, dementia, illness, present, ms, history, clinical, tratamento lítio níveis, relato caso, psychiatric illness, differential, possible, messages, caso revisão,